A/Prof Alex Andrianopoulos

Laboratory Head
Department of Genetics
University of Melbourne

+61 3 8344 5164
alex.a@unimelb.edu.au

Research Activities

We are studying a number of aspect of T. marneffei biology and pathogenicity and are particularly interested in understanding the molecular mechanisms which control the dimorphic switching and asexual development (conidiation) programs. Dimorphic switching is a temperature- and host-dependent response that allows T. marneffei to switch from a non-pathogenic hyphal growth form to the pathogenic yeast form. The yeast form is specialized to survive with host innate immune cells. Asexual development is the program the produce asexual spores, the infectious particles. We are teasing up the mechanisms that control these programs and examining their effects on growth and pathogenesis in the host.

Techniques/Expertise

DNA-protein interactions, genomics, transcriptomics

Disease Models

Macrophage cells, zebrafish, mice

Genetically Modified Organisms

Talaromyces marneffei (formerly Penicillium marneffei), Aspergillus fumigatus, Aspergillus nidulans

Other members with similar research interests

prev next

Prof Brian Cooke

Department of Microbiology Monash University SEE FULL PROFILE >

Dr Dieter Bulach

Department of Microbiology Monash University SEE FULL PROFILE >

Prof Tim Stinear

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Upcoming Events

  • Oct 29

    Cytokines 2017

    REGISTER | MORE INFO
  • Nov 1

    12th AUSTRALIAN INFLUENZA SYMPOSIUM 2017

    Peter Doherty Institute of Infection and Immunity REGISTER |
  • Nov 2

    Australian Respiratory Virology Meeting

    Peter Doherty Institute of Infection and Immunity REGISTER |