A/Prof Alex Andrianopoulos

Laboratory Head
Department of Genetics
University of Melbourne

+61 3 8344 5164
alex.a@unimelb.edu.au

Research Activities

We are studying a number of aspect of T. marneffei biology and pathogenicity and are particularly interested in understanding the molecular mechanisms which control the dimorphic switching and asexual development (conidiation) programs. Dimorphic switching is a temperature- and host-dependent response that allows T. marneffei to switch from a non-pathogenic hyphal growth form to the pathogenic yeast form. The yeast form is specialized to survive with host innate immune cells. Asexual development is the program the produce asexual spores, the infectious particles. We are teasing up the mechanisms that control these programs and examining their effects on growth and pathogenesis in the host.

Techniques/Expertise

DNA-protein interactions, genomics, transcriptomics

Disease Models

Macrophage cells, zebrafish, mice

Genetically Modified Organisms

Talaromyces marneffei (formerly Penicillium marneffei), Aspergillus fumigatus, Aspergillus nidulans

Other members with similar research interests

prev next

Prof Roger Nation

Monash Institute of Pharmaceutical Sciences Monash University SEE FULL PROFILE >

Prof Bill Heath

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Kate Jeffrey

Gastrointestinal Unit, Department of Medicine Massachusetts General Hospital, Harvard Medical School SEE FULL PROFILE >

Upcoming Events

  • Jun 23

    IgV Winter Seminar

    The Leveson
  • Jun 26

    Australian Society for Parasitology 2017 annual conference

    REGISTER | MORE INFO
  • Jun 27

    EMBO-EMBL Symposium: New Approaches and Concepts in Microbiology

    REGISTER | MORE INFO