Dr Anna Walduck
Senior Lecturer in Applied Microbiology, Laboratory Head
Research ActivitiesWe are interested in the interactions between host and pathogen in acute and chronic infections.
We are currently focussing on 2 main disease models:
Severe sepsis- Sepsis has a high mortality rate, there is an urgent need for adjunct therapies to improve patient outcomes. We are investigating immunological responses in patients with sepsis and looking at the potentially positive effects of low dose aspirin. This study is supported by experiments in animal and in vitro models of sepsis and biofilm related infections.
Understanding inflammation in the stomach to guide development of new vaccines against Helicobacter pylori. This bacterium infects up to half of the world population and causes chronic, potentially fatal disease. We are investigating the complex regulation of inflammation in the stomach to understand how to better design vaccines.
Novel Wound dressings using silver nano-structured fabrics.
In collaboration with Prof. Vipul Bansal's group ( RMIT) we are developing wound infection models to test novel wound dressings based on TCNQ. These fabrics have strong anti-microbial properties and are predicted to also enhance wound healing. See: https://www.rmit.edu.au/news/all-news/2016/april/nano-enhanced-textiles-clean-themselves-with-light/
Techniques/ExpertiseMouse models of infection
CollaborationsDr Odilia Wijburg
Assoc. Prof Damon Eisen (Victorian Infectious Disease Service), Dr Sukanya Raghavan (University of Gothenburg)
Prof Vipul Bansal & Dr Rajesh Ramanathan ( RMIT NanoBiotechnology Research Lab, Ian Potter NanoBioSensing Facility)
Disease ModelsH. pylori mouse model, vaccination
vaccination models in mice using attenuated Salmonella
S. aureus sepsis
Infection models in Leptin deficient mice ( ob/bo & db/db)
Other Lab MembersJacinta Ortega ( PhD candidate)
Dipesh Kumar ( Masters by Research)