Dr Anna Walduck
Senior Lecturer in Applied Microbiology, Laboratory Head
Research ActivitiesWe are interested in the interactions between host and pathogen in acute and chronic infections.
Severe sepsis- Sepsis has a high mortality rate, there is an urgent need for adjunct therapies to improve patient outcomes. We are investigating immunological responses in patients with sepsis and looking at the potentially positive effects of low dose aspirin. This study is supported by experiments in animal and in vitro models of sepsis and biofilm related infections.
Understanding inflammation in the stomach to guide development of new vaccines against Helicobacter pylori. This bacterium infects up to half of the world population and causes chronic, potentially fatal disease. We are investigating the complex regulation of inflammation in the stomach to understand how to better design vaccines.
Novel Wound dressings using silver nano-structured fabrics.
In collaboration with Prof. Vipul Bansal's group ( RMIT) we are developing wound infection models to test novel wound dressings based on TCNQ. These fabrics have strong anti-microbial properties and are predicted to also enhance wound healing. See: https://www.rmit.edu.au/news/all-news/2016/april/nano-enhanced-textiles-clean-themselves-with-light/
Two new projects on novel vaccination strategies in poultry:
1) Development of methods for the selection and delivery of vaccine antigens and other biologically active proteins using live microbial vectors. This project will design and test antigen expression constructs that will investigate different approaches to deliver multiple antigens in the most effective way, using live microbes as delivery vehicles.
2) Development of methods to enhance specific immune responses to vaccine antigens. There are opportunities to improve the effectiveness of vaccines by enhancing the quality, magnitude, and specificity of appropriate immune responses. The project will investigate the use of immune-enhancement sequences and co-delivered cytokines.
Both projects will be co-supervised by Professor Robert Moore and Dr Anna Walduck.
Techniques/ExpertiseMouse models of infection
CollaborationsDr Odilia Wijburg
Assoc. Prof Damon Eisen (Victorian Infectious Disease Service), Dr Sukanya Raghavan (University of Gothenburg)
Prof Vipul Bansal & Dr Rajesh Ramanathan ( RMIT NanoBiotechnology Research Lab, Ian Potter NanoBioSensing Facility)
Disease ModelsH. pylori mouse model, vaccination
vaccination models in mice using attenuated Salmonella
S. aureus sepsis
Infection models in Leptin deficient mice ( ob/bo & db/db)
Immune responses to vaccination in poultry
Other Lab MembersJacinta Ortega ( PhD candidate)
Dipesh Kumar ( Masters by Research)