Dr Mireille Lahoud

Laboratory Head, Dendritic Cell Receptors (Lahoud Laboratory)
Department of Biochemistry and Molecular Biology
Monash University

+61 3 9905 3788
mireille.lahoud@monash.edu

Research Activities

The Lahoud Laboratory have identified Clec9A, a novel DC-specific damage-associated molecular pattern receptor that is conserved in mice and humans.

Clec9A is specifically expressed by DC subsets that specialise in the uptake and presentation of antigen (Ag) from necrotic and apoptotic cells, and that are highly efficient at cross-presentation, that is the presentation of exogenous Ag in the MHC class I pathway. Clec9A binds dead cells, and plays an important role in presenting dead cell-derived Ag. Furthermore, Clec9A is an extremely promising candidate for immune modulation, as targeting Ag to DC via Clec9A markedly enhances both humoral and cellular immunity.

They have solved the crystal structure of the C-type lectin domain of human Clec9A to 1.8 Å. They have also determined two classes of Clec9A binding proteins, a cytoskeletal protein that reflects the binding of Clec9A to dead cells, and an independent protein which may be involved in downstream processing of Clec9A.

Their research is currently focused on characterising the molecular interactions that underpin Clec9A function, the role of these interactions in mediating immune responses, and the potential of targeting Clec9A for immune therapy.

Other Lab Members

Dr Rong Li
Hae-Young Park
Dr Peck Szee Tan

Other members with similar research interests

prev next

A/Prof David Anderson

Centre for Biomedical Research Burnet Institute SEE FULL PROFILE >

Ms Jun Gu

Viral Fusion Laboratory Burnet Institute SEE FULL PROFILE >

Mr Gaurav Sharma

Monash Institute of Pharmaceutical Sciences Monash University SEE FULL PROFILE >

Upcoming Events

  • Oct 29

    Cytokines 2017

    REGISTER | MORE INFO
  • Nov 1

    12th AUSTRALIAN INFLUENZA SYMPOSIUM 2017

    Peter Doherty Institute of Infection and Immunity REGISTER |
  • Nov 2

    Australian Respiratory Virology Meeting

    Peter Doherty Institute of Infection and Immunity REGISTER |