Abdalla Ali | Member Profile

Mr Abdalla Ali

PhD Student
Department of Microbiology and Immunology
University of Melbourne

abdallaa@student.unimelb.edu.au

One approach toward eliminating HIV latency is the activation of HIV viral production by latency reversal agents (LRAs) to induce virus mediated cytolysis or clearance through immune recognition (often called “shock and kill”). However, currently available LRAs are not specific for HIV, have off target effects and lack sufficient potency to eliminate infected T- cells. Nanoparticle delivery systems possess several advantages over more traditional drug delivery methods, and could potentially increase potency and reduce toxicity. However, there are challenges for uptake of nanoparticles in non-phagocytic resting T‐cells, the major reservoir of latent HIV.

Cell culture, flow cytometry, confocal microscopy, nanoparticles fabrication, PCR

HIV latency