Mrs Coralie Boulet

PhD Student
Department of Physiology, Anatomy and Microbiology
La Trobe University

19119643@students.latrobe.edu.au

Research Activities

Malaria is a life-threatening disease transmitted by mosquitoes. Every year, 200 million new infections and close to half a million deaths are due to malaria. Importantly, no effective anti-malaria vaccines are available. Furthermore, vector control strategies, although historically effective, do not fully prevent malaria transmission, and resistance against all available antimalarial drugs threatens to reverse the decrease in malaria morbidity and mortality observed in the recent years. Therefore, new antimalarial drugs and strategies are urgently needed. Plasmodium falciparum is the most virulent human malaria parasite. During its complex life cycle in humans, P. falciparum develops in erythrocytes. Mature erythrocytes lack organelles such as mitochondria and nucleus, but they present a programmed cell death mechanism termed eryptosis. We hypothesize that, in order to survive, P. falciparum needs to interact and interfere with its host eryptosis pathway.
We aim to identify druggable targets of the host erythrocyte, which would offer novel perspectives for host-directed anti-malarial therapy. Host-directed therapy would deprive the parasite from the most direct path to resistance, namely the selection of genotypes encoding a mutated target with reduced susceptibility to the drug.

Techniques/Expertise

Flow cytometry; Western Blots; Proteomics and phosphoproteomics.

Disease Models

Human malaria parasite: Plasmodium falciparum, in vitro culture of the erythrocytic asexual life cycle (in human erythrocytes)

Other Lab Members

Dr Teresa Carvalho

Other members with similar research interests

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Prof Elizabeth Hartland

Hudson Institute of Medical Research SEE FULL PROFILE >

Dr Seth Redmond

Institute of Vector Borne Disease Monash University SEE FULL PROFILE >

Dr Freya Fowkes

Centre for Biomedical Research Burnet Institute SEE FULL PROFILE >

Upcoming Events

  • Dec 8

    Australasian Society for Immunology Conference 2019

    Adelaide Convention Centre MORE INFO
  • Feb 19

    Lorne Infection and Immunity Conference 2020

    150 Mountjoy Parade, Lorne VIC 3232 MORE INFO
  • Feb 20

    19th International Congress on Infectious Diseases

    Kuala Lumpur Convention Centre MORE INFO