Prof Menno van Zelm

Lab Head
Immunology
Monash University

menno.vanzelm@monash.edu

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Licensing opportunities

Two patent application involving differential diagnosis of allergies, immune monitoring of allergen immunotherapy and quantification of immune memory to infection or vaccination, incl COVID-19 with recombinant allergen tetramers
etramers
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Contract research opportunities

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Other opportunities

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Research Activities

Research aims
In the past 10 years, our group has developed, patented and applied new technologies to ex vivo evaluate antigen-specific, human B-cell memory following infection, vaccination and treatment intervention. We will apply these new technologies for quantitative measurements of immune memory and thereby systematise the provision and use of an evidence base for clinical care and assessing vaccination strategies.Current research

Current research lines include:
  1. Defining the contribution of rare and common genetic variants to the severity and heterogeneity of disease in patients with predominantly antibody deficiency;
  2. The impact of persistent viral infections and intestinal microbiota in young children on T-cell and B-cell memory, and immune-mediated diseases (esp. Celiac disease and allergies);
  3. Abnormal IgE responses and memory B cells in allergic asthma and anaphylaxis, and how IgG induced by allergen-specific immunotherapy inhibits IgE-mediated effector cell activation.
  4. Diversity, specificity and durability of B-cell memory following vaccination or natural infection with zoonotic viruses (influenza, SARS-CoV2)

Techniques/Expertise

Human B and T cells; flow cytometry, single cell RNA-seq

Disease Models

primary immunodeficiency, allergy, COVID-19

Research Images

Other members with similar research interests

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Dr Lucy Cooper

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

Dr Lesley Hawes

Modelling and Analytical Epidemiology, Data and Intelligence, Public Health Victorian State Government SEE FULL PROFILE >

Dr Carolien van de Sandt

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Upcoming Events

  • Feb 15

    Lorne Infection and Immunity Conference 2023

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  • Feb 15

    Lorne Infection and Immunity Conference 2023

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