Research Activities

Throughout evolution, Nature has developed various mechanisms to produce, modify and transport biomolecules in specific cells. Inspired by these mechanisms, our research utilizes a multidisciplinary approach to develop new therapeutics. Our main goal is to develop oligonucleotides and peptide-based therapeutics. Considering the challenging chemistry associated with oligonucleotides and peptides that present different reactive functional groups, the newly developed chemistry needs to be selective, quantitative and bio-compatible, therefore our research also focuses on creating new chemistry tools for the selective modification of oligonucleotides and peptides, for efficient drug delivery into specific cells.
The key areas of interests:
1) Peptide Nucleic Acids (PNA) as antisense antibiotics
2) Backbone modified antisense oligonucleotides
3) Polymyxin based antibiotic drug development