Prof Peter Revill
Medical Scientist
Molecular Research and Development
Victorian Infectious Diseases Reference Laboratory
peter.revill@mh.org.au
"Development of new approaches to cure chronic HBV infection, which affects 296 million people worldwide."
Research Activities
- Have generated the largest panel of replication competent HBV clones available worldwide.
- Identifying virological biomarkers of treatment response and functional cure.
- Role of splicing in HBV pathogenesis
- Deep sequencing and haplotype analysis to predict treatment outcome.
- Impact of novel HBV variants on HBV replication and protein expression.
- Developing novel approaches to cure chronic HBV infection utilising in vitro and pre-clinical mouse models.
- HBV infection and the cellular Kinome.
- Sequence diversity of SARS-CoV-2.
Techniques/Expertise
Cell culture, transfection, infection studies, virus purification, electron microscopy, deep sequencing, bioinformatics and haplotype analysis, evolutionary analysis, RNA/DNA isolation, northern/Southern/western blotting, PCR/real-time and droplet digital PCR.Collaborations
National• Professor Alex Thompson, Dr Jacinta Holmes and Professor Kumar Visvanathan (St. Vincent's Hospital, Melbourne)
• Professor Peter Angus (Austin Hospital, Melbourne)
• Professor Winita Hardikar and Dr Elizabeth Bannister (Royal Children's Hospital, Melbourne)
• Professor Stephen Locarnini (VIDRL)
• Professor Sharon Lewin (Doherty Institute)
• ICE-HBV (ICE-HBV.org)
INTERNATIONAL
• Professor Zhenghong Yuan (Fudan University, Shanghai, China)
• Professor Anna Kramvis (University of the Witwatersrand, Johannesberg, South Africa)
• Professor Hwai-I Yang, Taiwan
• Gilead Sciences (USA)
Disease Models
- In vitro hepatocyte cell culture models for transfection of replication competent infectious HBV cDNAs, or infection with virions isolated from cell culture.
- Hydrodynamic injection of mice with replication competent clones of different HBV genotypes.
Other Lab Members
Post doctoral Scientists: Dr Margaret Littlejohn PhD, Dr Josef Wagner PhDSenior Research Assistant: Ms Vitina (Tina) Sozzi PhD
PhD Students: Yianni Droungas, Thao Huynh, Laura McCollough
