Dr Steven Heaton

Research Fellow
School of Biomedical Sciences
Monash University

steven.m.heaton@gmail.com

Research Activities

Steven is a molecular immunologist dissecting the exquisite assembly and function of antiviral immune systems and host-virus interplay. RIG-I-like receptors (RLRs), NOD-like receptors (NLRs), and Toll-like receptors (TLRs) sense virus components inside infected cells to trigger an antiviral state. In turn, viruses subvert immune and other host cell processes in order to replicate. Steven investigates the molecular mechanisms that control the innate immune system and methods by which viruses manipulate these mechanisms to facilitate their replication. By targeting multifunctional host proteins, viruses can enhance their replication by favourably manipulating multiple host cell processes at once. Drawing upon a wide range of techniques in molecular biology, cell biology, virology and structural biology, Steven's vision is to leverage such evolutionary ‘strengths’ of viruses against them, to design new kinds of antiviral and immune therapies that are effective yet resilient against virus escape mutants.

Techniques/Expertise

  • Analytical ultracentrifugation
  • Cell and virus culture
  • Confocal microscopy
  • Cytokine assays
  • ELISA
  • Enzymatic assays (ATPase, ubiquitination, phosphorylation, proteolysis)
  • FACS
  • Molecular cloning
  • NanoString
  • Protein trafficking assays
  • Proteomics (LC/MS, BioID)
  • Recombinant protein expression & purification
  • Reporter assays
  • Small-angle X-ray scattering
  • Western blotting

Disease Models

  • Parainfluenza virus (hPIV)
  • Respiratory syncitial virus (RSV)
  • Dengue virus (DenV)
  • HIV

Other Lab Members

Dr Natalie Borg
Dr Sarah Atkinson
Dr Michelle Audsley
Melissa Sweeney

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Upcoming Events

  • Mar 24

    World Tuberculosis Day

  • Mar 25

    ABCD7 - 7th Australian B Cell Dialogue

    Walter + Eliza Hall Institute MORE INFO
  • Apr 13

    29th European Congress of Clinical Microbiology & Infectious Diseases

    MORE INFO