Dr Paul Gilson
Laboratory Head
Centre for Biomedical Research
Burnet Institute
gilson@burnet.edu.au
Research Activities
Parasite invasionUnderstanding how malaria parasites invade their red blood cell hosts namely, the roles of parasite invasion ligands and cellular signalling events. Invasion ligands and signalling pathways are potential vaccine and drug targets.
Host cell modification
Malaria parasites extensively modify their red blood cell hosts by exporting 100s of proteins into them which help the parasite acquire nutrients to grow fast and to avoid host immunity. Knowing how parasites traffic proteins into their host cells is important because this could be a potential drug target.
Techniques/Expertise
Molecular biologyEngineering transgenic parasites with GFP and luciferase fusion proteins
Mutational analysis of parasites
Fluorescence microscopy, Super-resolution microscopy, Video microscopy
Proteomics, phosphoproteomics
Collaborations
A/Prof Tania de Koning-WardDr Travis Beddoe
Prof Jamie Rossjohn
Prof James Beeson
Dr Justin Boddey
Dr Brad Sleebs
Dr Paul Ramsland
Disease Models
Plasmodium falciparumGenetically Modified Organisms
Plasmodium falciparumWebsites
www.burnet.edu.au/www.burnet.edu.au/centres/20_centre_for_biomedical_research/working_groups/14_gilson_crabb_laboratory
www.burnet.edu.au/facilities/1_burnet_cell_imaging_facility
Other Lab Members
Dr Paul SandersDr Greta Weiss
Prof Brendan Crabb
Dr Hayley Bullen
Dr Ben Dickerman
Dr Annemarie Laumaea
Research Images
