Dr Paul Gilson

Laboratory Head
Centre for Biomedical Research
Burnet Institute

gilson@burnet.edu.au

Research Activities

Parasite invasion
Understanding how malaria parasites invade their red blood cell hosts namely, the roles of parasite invasion ligands and cellular signalling events. Invasion ligands and signalling pathways are potential vaccine and drug targets.

Host cell modification
Malaria parasites extensively modify their red blood cell hosts by exporting 100s of proteins into them which help the parasite acquire nutrients to grow fast and to avoid host immunity. Knowing how parasites traffic proteins into their host cells is important because this could be a potential drug target.

Techniques/Expertise

Molecular biology
Engineering transgenic parasites with GFP and luciferase fusion proteins
Mutational analysis of parasites
Fluorescence microscopy, Super-resolution microscopy, Video microscopy
Proteomics, phosphoproteomics

Collaborations

A/Prof Tania de Koning-Ward
Dr Travis Beddoe
Prof Jamie Rossjohn
Prof James Beeson
Dr Justin Boddey
Dr Brad Sleebs
Dr Paul Ramsland

Disease Models

Plasmodium falciparum

Genetically Modified Organisms

Plasmodium falciparum

Other Lab Members

Dr Paul Sanders
Dr Greta Weiss
Prof Brendan Crabb
Dr Hayley Bullen
Dr Ben Dickerman
Dr Annemarie Laumaea

Research Images

Other members with similar research interests

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Dr Diana Hansen

Infection and Immunity Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

A/Prof Neil O'Brien-Simpson

Melbourne Dental School University of Melbourne SEE FULL PROFILE >

Prof Ross Coppel

Faculty of Medicine, Nursing and Health Sciences Monash University SEE FULL PROFILE >

Upcoming Events

  • Oct 18

    VIIN Young Investigator Symposium 2018

    Walter and Eliza Hall Institute MORE INFO
  • Dec 2

    ASI 2018

    Pan Pacific Hotel MORE INFO
  • Dec 2

    10th HKU-Pasteur Immunology Course

    MORE INFO