A/Prof Neil O'Brien-Simpson

Program Leader
Melbourne Dental School
University of Melbourne

neil.obs@unimelb.edu.au

Research Activities

  1. Host repsonse to bacterial outer membrane vesicles (OMVs)
  2. Vaccine design and development - synthetic peptides and recombinant proteins
  3. Evaluation of the host response to bacterial oral infection
  4. Role of γδT cells, NKT cells and innate immune cells in bacterial oral infection
  5. Antimicrobial peptide development.
  6. Nanomaterials for vaccine delivery.
  7. Nanomaterials as antimicrobial compounds

Techniques/Expertise

  1. Peptide synthesis and modification, HPLC etc.
  2. Flow cytometry, Bioplex, MACS and FACS sorting, T cell proliferation, cytokine assays (ELISPOT, Bioplex), cell culture (T cells and subsets, B cells, macrophages, epithelial, endothelial etc)

Collaborations

2. Prof Dale Godfrey (Dept Immunology and Microbiology, University of Melbourne).
3. Prof Malcolm McConville (Dept Biochemistry, University of Melbourne)1
Prof John Wade (Howard Florey Institute)
Prof Greg Qiao (Dept Engineering, University of Melbourne)
Dr Maria Liaskos
Prof Frances Separovic
A/Prof Andrea O'Connor
Prof Stuart Dashper

Disease Models

Bacterial induced bone loss
bacterial induced peritonitis
Sepsis

Genetically Modified Organisms

αβ-TCR-/-, γδTCR-/-, IL-4-/-, IL-13-/-

Other Lab Members

Ms Yan Tan (Research assistant)
Dr Jason Lenzo
Dr James Holden
Mr William Singleton
Dr Alexis Gonzalez

Other members with similar research interests

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Dr Camila Franca

Population Health and Immunity Division The Walter and Eliza Hall Institute SEE FULL PROFILE >

Dr Louis Schofield

Infection and Immunity Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Prof James Beeson

Centre for Biomedical Research Burnet Institute SEE FULL PROFILE >

Upcoming Events

  • Jun 3

    7th International Symposium on Antimicrobial Peptides (AMP2020)

    Institut Pasteur MORE INFO
  • Jun 3

    Australasian Society for Infectious Diseases (ASID) Annual Scientific Meeting 2020

    Pullman Melbourne on the Park MORE INFO
  • Jun 3

    Impact of Environmental Changes on Infectious Diseases (IECID) 2020

    James Cook University, Singapore