A/Prof Neil O'Brien-Simpson

Program Leader
Melbourne Dental School
University of Melbourne

+61 3 9341 1550

Research Activities

  1. Host repsonse to bacterial outer membrane vesicles (OMVs)
  2. Vaccine design and development - synthetic peptides and recombinant proteins
  3. Evaluation of the host response to bacterial oral infection
  4. Role of γδT cells, NKT cells and innate immune cells in bacterial oral infection
  5. Antimicrobial peptide development


  1. Peptide synthesis and modification, HPLC etc.
  2. Flow cytometry, Bioplex, MACS and FACS sorting, T cell proliferation, cytokine assays (ELISPOT, Bioplex), cell culture (T cells and subsets, B cells, macrophages, epithelial, endothelial etc)


2. Prof Dale Godfrey (Dept Immunology and Microbiology, University of Melbourne).
3. Prof Malcolm McConville (Dept Biochemistry, University of Melbourne)1
Prof John Wade (Howard Florey Institute)
Prof Greg Qiao (Dept Engineering, University of Melbourne)
Dr Maria Liaskos

Disease Models

Bacterial induced bone loss
bacterial induced periotonitis

Genetically Modified Organisms

αβ-TCR-/-, γδTCR-/-, IL-4-/-, IL-13-/-

Other Lab Members

Ms Yan Tan (Research assistant)
Ms Gail Brammar (Research assistant), two PhD students
Dr Jason Lenzo
Dr James Holden

Other members with similar research interests

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Dr Sarah Hennebry

Freehills Patent Attorneys SEE FULL PROFILE >

Dr Grant Jenkin

Department of Microbiology Monash University SEE FULL PROFILE >

Prof Rob Moore


Upcoming Events

  • Mar 21

    ThymOz 2018

  • Mar 25

    2018 Antibody Biology and Engineering Gordon Research Conference

    Renaissance Tuscany Il Ciocco, Italy MORE INFO
  • Apr 22

    Malaria Experimental Genetics workshop

    Mahidol University Faculty of Tropical Medicine, Bangkok, Thailand MORE INFO