A/Prof Neil O'Brien-Simpson

Program Leader
Melbourne Dental School
University of Melbourne

neil.obs@unimelb.edu.au

Research Activities

  1. Host repsonse to bacterial outer membrane vesicles (OMVs)
  2. Vaccine design and development - synthetic peptides and recombinant proteins
  3. Evaluation of the host response to bacterial oral infection
  4. Role of γδT cells, NKT cells and innate immune cells in bacterial oral infection
  5. Antimicrobial peptide development.
  6. Nanomaterials for vaccine delivery.
  7. Nanomaterials as antimicrobial compounds

Techniques/Expertise

  1. Peptide synthesis and modification, HPLC etc.
  2. Flow cytometry, Bioplex, MACS and FACS sorting, T cell proliferation, cytokine assays (ELISPOT, Bioplex), cell culture (T cells and subsets, B cells, macrophages, epithelial, endothelial etc)

Collaborations

2. Prof Dale Godfrey (Dept Immunology and Microbiology, University of Melbourne).
3. Prof Malcolm McConville (Dept Biochemistry, University of Melbourne)1
Prof John Wade (Howard Florey Institute)
Prof Greg Qiao (Dept Engineering, University of Melbourne)
Dr Maria Liaskos
Prof Frances Separovic
A/Prof Andrea O'Connor
Prof Stuart Dashper

Disease Models

Bacterial induced bone loss
bacterial induced peritonitis
Sepsis

Genetically Modified Organisms

αβ-TCR-/-, γδTCR-/-, IL-4-/-, IL-13-/-

Other Lab Members

Ms Yan Tan (Research assistant)
Dr Jason Lenzo
Dr James Holden
Mr William Singleton
Dr Alexis Gonzalez

Other members with similar research interests

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Mr Simon Belluzzo

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Mohammad Azad

Monash Institute of Pharmaceutical Sciences Monash University SEE FULL PROFILE >

Dr Daniel Layton

Health and Biosecurity CSIRO SEE FULL PROFILE >

Upcoming Events

  • Jul 30

    2018 World Hepatitis Day Symposium: Preventing Disease, Preventing Deaths

    MORE INFO
  • Aug 13

    11th Australasian Viral Hepatitis Conference

    Adelaide Convention & Exhibition Centre MORE INFO
  • Aug 14

    14th International Congress of Parasitology

    EXCO MORE INFO