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Prof Neil O'Brien-Simpson

Program Leader
Melbourne Dental School
University of Melbourne

neil.obs@unimelb.edu.au

Research Activities

  1. Host repsonse to bacterial outer membrane vesicles (OMVs)
  2. Vaccine design and development - synthetic peptides and recombinant proteins
  3. Evaluation of the host response to bacterial oral infection
  4. Role of γδT cells, NKT cells and innate immune cells in bacterial oral infection
  5. Antimicrobial peptide development.
  6. Nanomaterials for vaccine delivery.
  7. Nanomaterials as antimicrobial compounds

Techniques/Expertise

  1. Peptide synthesis and modification, HPLC etc.
  2. Nanomaterial fabrication
  3. Flow cytometry, Bioplex, MACS and FACS sorting, T cell proliferation, cytokine assays (ELISPOT, Bioplex), cell culture (T cells and subsets, B cells, macrophages, epithelial, endothelial etc)

Collaborations

Prof John Wade (Howard Florey Institute)
Prof Greg Qiao (Dept Engineering, University of Melbourne)
Dr Maria Liaskos
Prof Frances Separovic
Prof Stuart Dashper
Prof Andrea O'Connor (Dept Biomedical Engineering, University of Melbourne)

Disease Models

Bacterial induced bone loss
bacterial induced peritonitis
Sepsis

Genetically Modified Organisms

αβ-TCR-/-, γδTCR-/-, IL-4-/-, IL-13-/-

ORCID ID

0000-0001-8462-5603

Other Lab Members

Dr Jason Lenzo
Dr James Holden
Mr William Singleton
Dr Alexis Gonzalez
Dr Sara Hadjigol

Other members with similar research interests

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Dr John Boyce

Department of Microbiology Monash University SEE FULL PROFILE >

Dr Gaoqian Feng

Centre for Biomedical Research Burnet Institute SEE FULL PROFILE >

A/Prof Fasseli Coulibaly

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

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