A/Prof Neil O'Brien-Simpson

Program Leader
Melbourne Dental School
University of Melbourne

neil.obs@unimelb.edu.au

Research Activities

  1. Host repsonse to bacterial outer membrane vesicles (OMVs)
  2. Vaccine design and development - synthetic peptides and recombinant proteins
  3. Evaluation of the host response to bacterial oral infection
  4. Role of γδT cells, NKT cells and innate immune cells in bacterial oral infection
  5. Antimicrobial peptide development.
  6. Nanomaterials for vaccine delivery.
  7. Nanomaterials as antimicrobial compounds

Techniques/Expertise

  1. Peptide synthesis and modification, HPLC etc.
  2. Flow cytometry, Bioplex, MACS and FACS sorting, T cell proliferation, cytokine assays (ELISPOT, Bioplex), cell culture (T cells and subsets, B cells, macrophages, epithelial, endothelial etc)

Collaborations

2. Prof Dale Godfrey (Dept Immunology and Microbiology, University of Melbourne).
3. Prof Malcolm McConville (Dept Biochemistry, University of Melbourne)1
Prof John Wade (Howard Florey Institute)
Prof Greg Qiao (Dept Engineering, University of Melbourne)
Dr Maria Liaskos
Prof Frances Separovic
A/Prof Andrea O'Connor
Prof Stuart Dashper

Disease Models

Bacterial induced bone loss
bacterial induced peritonitis
Sepsis

Genetically Modified Organisms

αβ-TCR-/-, γδTCR-/-, IL-4-/-, IL-13-/-

Other Lab Members

Ms Yan Tan (Research assistant)
Dr Jason Lenzo
Dr James Holden
Mr William Singleton
Dr Alexis Gonzalez

Other members with similar research interests

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Dr Grant Jenkin

Department of Microbiology Monash University SEE FULL PROFILE >

Dr Odilia Wijburg

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Andrew Bean

Australian Animal Health Laboratory CSIRO SEE FULL PROFILE >

Upcoming Events

  • Aug 5

    Australasian Viral Hepatitis Elimination Conference 2019

    Novotel Sydney Brighton Beach, Brigton-Le-Sands MORE INFO
  • Aug 13

    International Veterinary Immunology Symposium (IVIS) 2019

    Renaissance Seattle Hotel 515 Madison Street, Seattle, Washington 98104, USA MORE INFO
  • Aug 26

    Student Open Day Hudson Institute of Medical Research

    Hudson Institute of Medical Research and Monash University MORE INFO