A/Prof Heidi Drummer
Program Director, Disease Eliination
"VIIN has allowed me to identify new collaborators and industry partners to conduct my research program. "
Licensing opportunitiesVaccine candidates for HCV
Contract research opportunitiesCapacity to produce recombinant proteins in mammallian systems. Stable cell line development for high level protein production.
Narasimhulu, VGS, Bellamy-Mcintyre, AK, Laumaea, AE, Lay, CS, Harrison, DN, King, HaD, Drummer, HE & Poumbourios, P, 2018, Distinct functions for the membrane-proximal ectodomain region (MPER) of HIV-1 gp41 in cell-free and cell-cell viral transmission and cell-cell fusion. J Biol Chem, 293, 6099
Lucas, M, Deshpande, P, James, I, Rauch, A, Pfafferott, K, Gaylard, E, Merani, S, Plauzolles, A, Lucas, A, Mcdonnell, W, Kalams, S, Pilkinton, M, Chastain, C, Barnett, L, Prosser, A, Mallal, S, Fitzmaurice, K, Drummer, H, Ansari, MA, Pedergnana, V, Barnes, E, John, M, Kelleher, D, Klenerman, P & Gaudieri, S, 2018, Evidence of CD4(+) T cell-mediated immune pressure on the Hepatitis C virus genome. Sci Rep, 8, 7224
Gu, J, Hardy, J, Boo, I, Vietheer, P, Mccaffrey, K, Alhammad, Y, Chopra, A, Gaudieri, S, Poumbourios, P, Coulibaly, F & Drummer, HE, 2018, Escape of Hepatitis C Virus from Epitope I Neutralization Increases Sensitivity of Other Neutralization Epitopes. J Virol, 92,
Research ActivitiesWe aim to develop novel vaccine candidates for Hepatitis C and HIV and seek to understand mechanisms of viral entry, immune evasion and natural immunity to Hepatitis C.
Techniques/ExpertiseMammalian, insect and bacterial protein expression systems, cell line development, monoclonal antibody production and characterization, single cell B cell isolation and IgG production, evaluation of immune responses to vaccine candidates, virus neutralization assays, protein purification and characterization, structural biology.
CollaborationsDr Fasseli Coulibaly
Dr Pantelis Poumbourios
Professor Ellie Barnes
A/Prof Joseph Torresi