Miss Brianna Jesaveluk

PhD Student
Centre for Biomedical Research
Burnet Institute


Latest News

Latest publication: Lactic acid from vaginal microbiota enhances cervicovaginal epithelial barrier integrity by promoting tight junction protein expression

Research Activities

I commenced my PhD in 2020 at the Burnet Institute through Monash University. I am particularly interested in the prevention of diseases that are endemic in developing nations, such as HIV,  through combining my areas of interest in microbiology, immunology and international development. My project is titled 'the impact of the vaginal environment on epithelial barrier function and HIV susceptibility'.

Approximately half of new human immunodeficiency virus (HIV) infections globally occur in women, where the virus establishes infection primarily through the lower female reproductive tract (FRT). There are several factors that influence viral transmission, including effects of the vaginal microbiota (and their acid metabolites) as well female sex hormones on epithelial barrier integrity. My project will determine the impact of the vaginal environment on epithelial barrier function and the implications for HIV susceptibility by investigating the modulation of signalling pathways, gene expression and protein production by estrogen and metabolic products of commensal FRT bacteria.

I have been based at the Burnet Institute since 2018, where I first completed my Bachelor of Science (Honours), with my research project titled 'the antiviral activity of bat APOBEC3 proteins'. Following the completion of my Honours I worked jointly as a research assistant with the Retroviral Biology and Antivirals Laboratory and the Viral Entry and Vaccines Laboratory. 


Molecular cloning, cell culture, PCR, viral infectivity assays, PC3

Other members with similar research interests

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Prof Johnson Mak

School of Medicine Deakin University SEE FULL PROFILE >

Prof Sharon Lewin

Peter Doherty Institute University of Melbourne SEE FULL PROFILE >

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