Dr Aaron Irving
Emerging Infectious Diseases
Duke-NUS Medical School
Research ActivitiesPattern recognition receptors and activation of innate immunity and inflammasome.
Viral infection and innate immunity.
Differences in innate immune activation and inflammasome sensing between bats and humans.
Techniques/ExpertiseMammalian cell culture (epithelial cells, bone marrow derived macrophages/dcs, macrophage lines, T cell lines, PBMCs, lung, liver, kidney, whole splenocytes)
Immuno-detection techniques (eg. ELISA, Western blotting, flow cytometry)
NGS and proteomics
TLR ligand screening
Gene knockdown (RNAi)
Confocal and live-cell microscopy
Molecular Biology (cloning, mutagenesis, library screening)
Viral infection assays (NBV, HeV, SeV, MuV, Zika, DV, SFV, Adv5, HSV1, EMCV, RSV, VZV)
Cellular movement (cellular migration, phagocytic uptake)
Genetically Modified Organismsmice
bat (KO cells)