Dr Aaron Irving

Postdoctoral Fellow
Emerging Infectious Diseases
Duke-NUS Medical School

aaron.irving@duke-nus.edu.sg

Research Activities

Pattern recognition receptors and activation of innate immunity and inflammasome.
Viral infection and innate immunity.
Differences in innate immune activation and inflammasome sensing between bats and humans.

Techniques/Expertise

Mammalian cell culture (epithelial cells, bone marrow derived macrophages/dcs, macrophage lines, T cell lines, PBMCs, lung, liver, kidney, whole splenocytes)
Immuno-detection techniques (eg. ELISA, Western blotting, flow cytometry)
inflammasome activation
NGS and proteomics
TLR ligand screening
Gene knockdown (RNAi)
Confocal and live-cell microscopy
Molecular Biology (cloning, mutagenesis, library screening)
Viral infection assays (NBV, HeV, SeV, MuV, Zika, DV, SFV, Adv5, HSV1, EMCV, RSV, VZV)
Cellular movement (cellular migration, phagocytic uptake)

Disease Models

inflammasome
virus infections

Genetically Modified Organisms

mice
bat (KO cells)

Other Lab Members

Linfa wang

Other members with similar research interests

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Prof Fabienne Mackay

School of Biomedical Sciences University of Melbourne SEE FULL PROFILE >

Prof Jamie Rossjohn FAA FLSW FAHMS FMedSci

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

Dr Erika Duan

La Trobe Institute for Molecular Science La Trobe University SEE FULL PROFILE >

Upcoming Events

  • Feb 20

    Lorne Infection and Immunity Conference 2019

    Cumberland Lorne Resort MORE INFO
  • Feb 21

    Antimicrobials 2019

    Sheraton Grand Sydney Hyde Park MORE INFO
  • Mar 24

    World Tuberculosis Day