Dr Aaron Irving

Postdoctoral Fellow
Emerging Infectious Diseases
Duke-NUS Medical School

aaron.irving@duke-nus.edu.sg

Research Activities

Pattern recognition receptors and activation of innate immunity and inflammasome.
Viral infection and innate immunity.
Differences in innate immune activation and inflammasome sensing between bats and humans.

Techniques/Expertise

Mammalian cell culture (epithelial cells, bone marrow derived macrophages/dcs, macrophage lines, T cell lines, PBMCs, lung, liver, kidney, whole splenocytes)
Immuno-detection techniques (eg. ELISA, Western blotting, flow cytometry)
inflammasome activation
NGS and proteomics
TLR ligand screening
Gene knockdown (RNAi)
Confocal and live-cell microscopy
Molecular Biology (cloning, mutagenesis, library screening)
Viral infection assays (NBV, HeV, SeV, MuV, Zika, DV, SFV, Adv5, HSV1, EMCV, RSV, VZV)
Cellular movement (cellular migration, phagocytic uptake)

Disease Models

inflammasome
virus infections

Genetically Modified Organisms

mice
bat (KO cells)

Other Lab Members

Linfa wang

Other members with similar research interests

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Dr Jacqueline Heath

Melbourne Dental School University of Melbourne SEE FULL PROFILE >

Dr Marina Harper

Department of Microbiology Monash University SEE FULL PROFILE >

A/Prof Ashley Mansell

Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Dec 1

    World AIDS Day

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  • Dec 5

    2019 Hot Topics in Infection & Immunity in Children

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  • Dec 8

    Australasian Society for Immunology Conference 2019

    Adelaide Convention Centre MORE INFO