Dr Aaron Irving

Postdoctoral Fellow
Emerging Infectious Diseases
Duke-NUS Medical School

aaron.irving@duke-nus.edu.sg

Research Activities

Pattern recognition receptors and activation of innate immunity and inflammasome.
Viral infection and innate immunity.
Differences in innate immune activation and inflammasome sensing between bats and humans.

Techniques/Expertise

Mammalian cell culture (epithelial cells, bone marrow derived macrophages/dcs, macrophage lines, T cell lines, PBMCs, lung, liver, kidney, whole splenocytes)
Immuno-detection techniques (eg. ELISA, Western blotting, flow cytometry)
inflammasome activation
NGS and proteomics
TLR ligand screening
Gene knockdown (RNAi)
Confocal and live-cell microscopy
Molecular Biology (cloning, mutagenesis, library screening)
Viral infection assays (NBV, HeV, SeV, MuV, Zika, DV, SFV, Adv5, HSV1, EMCV, RSV, VZV)
Cellular movement (cellular migration, phagocytic uptake)

Disease Models

inflammasome
virus infections

Genetically Modified Organisms

mice
bat (KO cells)

Other Lab Members

Linfa wang

Other members with similar research interests

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Prof Michael Hickey

Department of Medicine - Monash Medical Centre Monash University SEE FULL PROFILE >

Dr Prasad Paradkar

Health and Biosecurity CSIRO SEE FULL PROFILE >

Dr KE TANG

Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Jun 2

    15th Symposium of the International Society of Vascular Infectious Diseases

    MORE INFO
  • Jun 3

    17th International TNF Superfamily Conference

    Asilomar Conference Grounds, 800 Asilomar Ave, Pacific Grove, CA 93950 MORE INFO
  • Jun 13

    VIIN Careers Evening 2019

    Burnet Institute MORE INFO