A/Prof Aaron Irving
Zhejiang University School of Medicine
Research ActivitiesPattern recognition receptors and activation of innate immunity and the inflammasome.
Viral infection and innate immunity, Host-pathogen interactions.
Differences in innate immune activation and inflammasome sensing between bats and humans and applications to human health - comparative immunology.
Techniques/ExpertiseMammalian cell culture (epithelial cells, bone marrow derived macrophages/dcs, macrophage lines, T cell lines, PBMCs, lung, liver, kidney, whole splenocytes)
Immuno-detection techniques (eg. ELISA, Western blotting, flow cytometry)
NGS and proteomics
TLR ligand screening
Gene knockdown (RNAi)
Confocal and live-cell microscopy
Molecular Biology (cloning, mutagenesis, library screening)
Viral infection assays (NBV, HeV, SeV, MuV, Zika, DV, SFV, Adv5, HSV1, EMCV, RSV, VZV)
Cellular movement (cellular migration, phagocytic uptake)
primary bat cells
in vivo bat infections
MERS-CoV, SARS-CoV-2, PRV, IAV, HSV, DENV, ZIKV, bat IAVs
Genetically Modified Organismsmice
bat (KO cells)