Dr Seth Masters

Laboratory Head
Inflammation Division
Walter and Eliza Hall Institute of Medical Research

masters@wehi.edu.au

Research Activities

Research in the Masters lab is focused on inflammation from the innate immune system. This can happen in many different contexts, for example during a bacterial or virus infection; when cells die during an organ or tissue transplant; or when genetic mutations activate innate immune pathways. The innate immune response is also fundamentally involved in the pathogenesis of many chronic inflammatory diseases like inflammatory bowel disease, type 2 diabetes, and neuroinflammatory conditions.

Techniques/Expertise

Inflammasome activation
Non apoptotic cell death, eg Pyroptosis and Necroptosis
CRISPR

Collaborations

Prof Luke O'Neill (Trinity College Dublin)
Dr Daniel Kastner (NIH)

Disease Models

Genetic autoinflammatory disease
Infections (Toxo, LCMV, Listeria)
Inflammatory bowel disease
Type 2 diabetes
Neuroinflammation

Genetically Modified Organisms

Inflammasome activation mice (NLRP1 and NLRP3)
Inflammasome deficient mice (many eg. Caspase-1, ASC, NLRP3)
Mice lacking cell death genes (many eg Caspase-11)

Other Lab Members

Senior Postdoctoral Fellow:
Motti Gerlic, BSc, PhD Israel
Postdoctoral Fellow:
Man Lyang Kim, BSc, MSc South Korea, PhD Basel
Postgraduate Student:
Paul Baker, BSc(Hons) Adelaide
Undergraduate Student:
Damian D'Silva, BSc RMIT
Katelyn Chalker, BSc Uni Queensland

Other members with similar research interests

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Dr Xiangting Chen

Physiology Monash University SEE FULL PROFILE >

A/Prof Bruce Loveland

Centre for Biomedical Research Burnet Institute SEE FULL PROFILE >

Dr Latasha Abeynaike

Respiratory/Monash University Dept Immunology Alfred Hospital SEE FULL PROFILE >

Upcoming Events

  • Jun 20

    ASM Microbe 2019

    Moscone Center 747 Howard St. San Francisco, CA 94103 MORE INFO
  • Jun 27

    4th Asia-Pacific AIDS & Co-Infections Conference

    MORE INFO
  • Jun 30

    Annual Meeting of the Australian Society for Microbiology 2019

    Adelaide Convention Centre MORE INFO