Prof A Richard Kitching

Group Leader
Department of Medicine - Monash Medical Centre
Monash University

Research Activities

We do not have a good understanding of how different forms of glomerulonephritis occur. Drugs that are current standard of care have significant toxic effects - without a better understanding of how disease occurs it will be difficult to rationally apply or develop new treatments. Prof Kitching's research aims to help understand the pathogenesis of immune renal disease. He has made important contributions to our understanding of how leukocytes mediate kidney disease in several areas.
  •  How T helper cells direct nephritogenic immune responses.
  •  Autoreactive CD4+ cells mediate injury in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis.
  • T cell epitopes in autoimmune renal dsiease
  •  The unique biology of glomerular leukocyte recruitment and behaviour revealed by intravital and multiphoton microscopy (with Prof Michael Hickey)
  • Leukocytes in acute kidney injury

Disease Models

1) Our group uses a variety of models of murine glomerulonephritis, some of which are unique to our group.
These include autoimmune and non-autoimmune models, and models mediated by humoral
 and cellular effectors.
We model all major types of rapidly progressive glomerulonephritis: anti-glomerular basement membrane disease, lupus nephritis and ANCA-associated vasculitis
2) We study acute kidney injury using murine models of cisplatin-induced acute kidney injury and unilateral and bilateral ischemia reperfusion injury
3) Although not currently a major research focus, renal fibrosis using murine unilateral ureteric obstruction as been used in the recent past.

Genetically Modified Organisms

1) Mice geneticaly deficient in a number of different elements of the immune system
2) HLA transgenic mice
3) TCR transgenic mice specific for myeloperoxidase

Other members with similar research interests

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Dr Seth Masters

Inflammation Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Prof Alex Andrianopoulos

School of BioSciences University of Melbourne SEE FULL PROFILE >

Dr Rebecca Gorrell

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

Upcoming Events

  • Jun 20

    ASM Microbe 2019

    Moscone Center 747 Howard St. San Francisco, CA 94103 MORE INFO
  • Jun 27

    4th Asia-Pacific AIDS & Co-Infections Conference

  • Jun 30

    Annual Meeting of the Australian Society for Microbiology 2019

    Adelaide Convention Centre MORE INFO