Dr Joanna Groom
Walter & Eliza Hall Institute of Medical Research
Research ActivitiesOur immune system requires flexibility to protect us against numerous and varied infectious agents. Following infection, immune cells integrate pathogen-specific signals to promote the dynamic migration and interactions required to determine cell differentiation and function. Our lab investigates multiple mechanisms that work together to direct flexible protective responses.
1. Chemokine control of T cell host defence and memory
2. Diversity in germinal centre (GC) reactions generated by distinct TFH differentiation
3. Modulation of immune responses by the immunosuppressive chemokines
Our research combines pathogen models, reporter mice, advanced imaging, and transcriptional analysis to dissect the networks that control cell fate and enable flexibility in immune responses. We use these advanced approaches to identify new therapeutic avenues to drive immune responses either towards protection or away from autoimmunity.
Techniques/ExpertiseAdvanced Imaging - 3D whole organ imaging (with clearing), live multi-photon and confocal, Viral models of infection, Transcriptional analysis, Chemokines, Cell migration, T cell-DC interactions, GC biology, MHC II tetramers.
Disease ModelsViral Infection models - Influenza, LCMV, HSV-1
Bacterial infection models - Listeria, Toxoplasma
Genetically Modified OrganismsCXCR3 family - reporters and knockouts
TCR Tgs for LCMV, HSV-I