Dr Joanna Groom

Laboratory Head
Molecular Immunology
Walter & Eliza Hall Institute of Medical Research

groom@wehi.edu.au

Research Activities

Our immune system requires flexibility to protect us against numerous and varied infectious agents. Following infection, immune cells integrate pathogen-specific signals to promote the dynamic migration and interactions required to determine cell differentiation and function. Our lab investigates multiple mechanisms that work together to direct flexible protective responses.

1. Chemokine control of T cell host defence and memory
2. Diversity in germinal centre (GC) reactions generated by distinct TFH differentiation 
3. Modulation of immune responses by the immunosuppressive chemokines      

Our research combines pathogen models, reporter mice, advanced imaging, and transcriptional analysis to dissect the networks that control cell fate and enable flexibility in immune responses. We use these advanced approaches to identify new therapeutic avenues to drive immune responses either towards protection or away from autoimmunity.    

Techniques/Expertise

Advanced Imaging - 3D whole organ imaging (with clearing), live multi-photon and confocal, Viral models of infection, Transcriptional analysis, Chemokines, Cell migration, T cell-DC interactions, GC biology, MHC II tetramers.

Disease Models

Viral Infection models - Influenza, LCMV, HSV-1
Bacterial infection models - Listeria, Toxoplasma

Genetically Modified Organisms

CXCR3 family - reporters and knockouts
Tbx21 floxed
TCR Tgs for LCMV, HSV-I

Other members with similar research interests

prev next

Dr Julia Marchingo

Immunology Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Dr Aaron Irving

Emerging Infectious Diseases Duke-NUS Medical School SEE FULL PROFILE >

Dr Scott Mueller

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Upcoming Events

  • Jun 2

    15th Symposium of the International Society of Vascular Infectious Diseases

    MORE INFO
  • Jun 3

    17th International TNF Superfamily Conference

    Asilomar Conference Grounds, 800 Asilomar Ave, Pacific Grove, CA 93950 MORE INFO
  • Jun 13

    VIIN Careers Evening 2019

    Burnet Institute MORE INFO