A/Prof Mark Chong

Laboratory Head
St Vincents Institute

mchong@svi.edu.au

Research Activities

My laboratory has two general research interests. Firstly, we are interested in the molecular mechanisms that control immune cell development. We wish to understand how the cells of immune system are produced in appropriate numbers and with appropriate functional properties in order to protect against pathogens without causing autoimmunity. We are particularly interested in the differentiation of T cells in the thymus and of haematopoietic stem cells in the bone marrow. Secondly, we are interested in the biogenesis and function of non-coding RNAs. We study how these RNAs are transcribed and processed in order to generate functional molecules. We are also interested in understanding the regulation of the microRNA machinery.

Techniques/Expertise

GM mouse models, gene targeting, next generation sequencing, single cell sequencing, transcriptomics, computational biology, proteomics, shRNA/siRNA/CRISPR

Other members with similar research interests

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Dr Nicole Mifsud

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

Prof Tim Stinear

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Mr Benjamin Broomfield

Immunology Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

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