Research Activities
My laboratory has two general research interests. Firstly, we are
interested in the molecular mechanisms that control immune cell
development. We wish to understand how the cells of immune system are
produced in appropriate numbers and with appropriate functional
properties in order to protect against pathogens without causing
autoimmunity. We are particularly interested in the differentiation of T
cells in the thymus and of haematopoietic stem cells in the bone
marrow. Secondly, we are interested in the biogenesis and function of
non-coding RNAs. We study how these RNAs are transcribed and processed
in order to generate functional molecules. We are also interested in
understanding the regulation of the microRNA machinery.
Research Keywords
Researching in the following areas:
T cells, Dendritic cells, Immune system development, Genomics, MicroRNA
Techniques/Expertise
GM mouse models, gene targeting, next generation sequencing, single cell sequencing, transcriptomics, computational biology, proteomics, shRNA/siRNA/CRISPR
