Prof Alex Andrianopoulos

Laboratory Head
School of BioSciences
University of Melbourne

alex.a@unimelb.edu.au

Research Activities

We are studying a number of aspect of T. marneffei biology and pathogenicity and are particularly interested in understanding the molecular mechanisms which control the dimorphic switching and asexual development (conidiation) programs. Dimorphic switching is a temperature- and host-dependent response that allows T. marneffei to switch from a non-pathogenic hyphal growth form to the pathogenic yeast form. The yeast form is specialized to survive with host innate immune cells. Asexual development is the program the produce asexual spores, the infectious particles. We are teasing up the mechanisms that control these programs and examining their effects on growth and pathogenesis in the host.

Techniques/Expertise

DNA-protein interactions, genomics, transcriptomics

Disease Models

Macrophage cells, zebrafish, mice

Genetically Modified Organisms

Talaromyces marneffei (formerly Penicillium marneffei), Aspergillus fumigatus, Aspergillus nidulans

Other members with similar research interests

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Prof Jian Li

Monash Institute of Pharmaceutical Sciences Monash University SEE FULL PROFILE >

Dr Tom Brodnicki

Immunology and Diabetes Unit St Vincents Institute SEE FULL PROFILE >

Dr Rhys Allan

Molecular Immunology Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Dec 2

    ASI 2018

    Pan Pacific Hotel MORE INFO
  • Dec 2

    10th HKU-Pasteur Immunology Course

    MORE INFO
  • Feb 20

    Lorne Infection and Immunity Conference 2019

    Cumberland Lorne Resort MORE INFO