Prof Alex Andrianopoulos

Laboratory Head
School of BioSciences
University of Melbourne

alex.a@unimelb.edu.au

Research Activities

We are studying a number of aspect of T. marneffei biology and pathogenicity and are particularly interested in understanding the molecular mechanisms which control the dimorphic switching and asexual development (conidiation) programs. Dimorphic switching is a temperature- and host-dependent response that allows T. marneffei to switch from a non-pathogenic hyphal growth form to the pathogenic yeast form. The yeast form is specialized to survive with host innate immune cells. Asexual development is the program the produce asexual spores, the infectious particles. We are teasing up the mechanisms that control these programs and examining their effects on growth and pathogenesis in the host.

Techniques/Expertise

DNA-protein interactions, genomics, transcriptomics

Disease Models

Macrophage cells, zebrafish, mice

Genetically Modified Organisms

Talaromyces marneffei (formerly Penicillium marneffei), Aspergillus fumigatus, Aspergillus nidulans

Other members with similar research interests

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Ms Caitlin Rowe

Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

Dr Simon Royce

Pharmacology Monash University SEE FULL PROFILE >

Prof Phil Sutton

Infection and Immunity Theme Murdoch Childrens Research Institute SEE FULL PROFILE >

Upcoming Events

  • Aug 16

    12th Australasian Viral Hepatitis Conference

    The Sofitel Brisbane MORE INFO
  • Aug 23

    19th International Symposium on Staphylococci and Staphylococcal Infections

    Perth Convention and Exhibition Centre MORE INFO
  • Sep 11

    Zoonoses Conference

    MORE INFO