Prof Alex Andrianopoulos

Laboratory Head
School of BioSciences
University of Melbourne

alex.a@unimelb.edu.au

Research Activities

We are studying a number of aspect of T. marneffei biology and pathogenicity and are particularly interested in understanding the molecular mechanisms which control the dimorphic switching and asexual development (conidiation) programs. Dimorphic switching is a temperature- and host-dependent response that allows T. marneffei to switch from a non-pathogenic hyphal growth form to the pathogenic yeast form. The yeast form is specialized to survive with host innate immune cells. Asexual development is the program the produce asexual spores, the infectious particles. We are teasing up the mechanisms that control these programs and examining their effects on growth and pathogenesis in the host.

Techniques/Expertise

DNA-protein interactions, genomics, transcriptomics

Disease Models

Macrophage cells, zebrafish, mice

Genetically Modified Organisms

Talaromyces marneffei (formerly Penicillium marneffei), Aspergillus fumigatus, Aspergillus nidulans

Other members with similar research interests

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Dr Diana Hansen

Infection and Immunity Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Mr Simon Belluzzo

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Catherine Kennedy

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Upcoming Events

  • Oct 18

    17th International Congress of Immunology

    MORE INFO
  • Oct 20

    7th Annual Meeting of the International Cytokine & Interferon Society

    Hofburg Conference Center, MORE INFO
  • Oct 28

    Australian Influenza Symposium

    Queensland University of Technology Gardens Point Campus REGISTER | MORE INFO