Dr Boris Novakovic

Team Leader / Senior Research Officer
Cell Biology
Murdoch Childrens Research Institute

boris.novakovic@mcri.edu.au

Research Activities

I am a trained molecular biologist with an interest in epigenetics of human immune cell function and disease. I am particularly interested in applying complementary epigenetic techniques to profile different aspects of chromatin structure and to integrate these data to explain biology. I have experience in the generation and analysis of comprehensive epigenomics data on human primary monocytes, including ChIP, ATAC, and RNA-seq. I gained these skills during a 4 year postdoc in the lab of Prof Hendrik Stunnenberg at Radboud University (Nijmegen, The Netherlands), working on the EU funded BLUEPRINT project, which is part of the International Human Epigenome Consortium (IHEC). Such analysis has resulted in two publications in Cell and other leading journals in the field of immunology. These publications were the result of a close collaboration with the lab of Professor Mihai Netea, the pioneer in the field of ‘trained immunity’. In 2018 I joined MCRI as a Senior Research Officer ‘team leader’ in the lab of Professor Richard Saffery. I am currently using epigenomic techniques to study innate immunity, and have ongoing collaborations with researchers in the Netherlands and recently established collaborations with researchers in Australia to study the molecular events in a variety of human immune diseases.

Techniques/Expertise

RNA-sequencing, ChIP-sequencing, ATAC-seq, DNA methylation, monocyte culture

Collaborations

Prof Mihai Netea (Nijmegen, The Netherlands)
Prof Dave Burgner (MCRI, Melbourne)
Prof Nigel Curtis (MCRI, Melbourne)
Dr Debby van Riel (Erasmus MC, The Netherlands)
Prof Katie Flanagan (U Tasmania, Australia)
Dr Melanie Neeland (MCRI, Melbourne)
Dr Sebastian Weis (Jena, Germany)

Disease Models

Childhood infection, allergy, obesity, human vaccination trials

Other Lab Members

Bowon Kim
Rebecca Shepherd
Samira Imran
Sachintha Wijegunasekara

Other members with similar research interests

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Upcoming Events

  • Dec 1

    World AIDS Day

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  • Dec 5

    2019 Hot Topics in Infection & Immunity in Children

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  • Dec 8

    Australasian Society for Immunology Conference 2019

    Adelaide Convention Centre MORE INFO