A/Prof Ashley Mansell
Laboratory Head
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research
ashley.mansell@hudson.org.au
"Through the Lorne Infection and Immunity meeting, I met the CEO of a US based Biotech startup and began conducting contract research on their behalf. Through this, we developed a novel inflammasome inhibitor and I have now joined this company called Adiso Therapeutics as Head of Translational Sciences while also maintaining my laboratory and adjunct position at Hudson Institute."
Research Activities
Pattern Recognition Receptors based research investigating:- The Toll-like receptor (TLRs), RIG-like Helicase (RLHs) and NOD-like receptors (NLRs)
- Signal transduction pathways initiated upon recognition of both pathogen and endogenous TLR ligands
- Structure/Function analysis of TLR signaling mediators
- Negative regulation of these pathways to prevent chronic inflammation
- Pathogen immunomodulation of these pathways/receptors
Techniques/Expertise
activation of NF-kB and IFNγ by various meanscell biology
TLR screening
Viral infections
TLR expressing cell lines
TLR/PRR/Signaling pathway
immortalized gene-deficient BMMs
Inflammasome Imaging
Collaborations
Luke O'Neill, Trinity College DublinKatherine Fitzgerald, University of Massachusetts
Eicke Latz, University of Bonn
A/Prof Richard Ferrero
Prof Brendan Jenkins
Dr Michelle Tate
Disease Models
Septic ShockViral Infection
Inflammasome
Influenza A virus
E. coli
Silicosis
Genetically Modified Organisms
ASC-/-
NLRP3-/-
Websites
www.monashinstitute.org/centres/ciiid/toll-like-receptor-signalling.htmlhudson.org.au/pattern-recognition-receptors-and-inflammation/
adisotx.com/
Research Images
