Prof Paul Hertzog

Director
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research

paul.hertzog@hudson.org.au

Licensing opportunities

Interferon epsilon therapeutic in cancer and infectious disease
ease
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Contract research opportunities

KOL / general expertise in inflammatory disease, cancer immunology, infections
screening assays
disease models
dels
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Research Activities

Overall interest is in the molecular regulation of signal transduction in innate immunity. In particular our group is interested in pattern recognition receptor signaling, the elicited transcriptional responses including IRF, STAT, ETS and NFκB pathways and the ensuing cytokine responses. The particular cytokines of interest are the type I interferons (IFNs). We investigate the mechanisms of signaling beginning at engagement of the receptors, IFNAR1 and IFNAR2. Receptor function is studies using genetically modified mouse models, protein-protein interactions, structural biology, imaging and signal transduction studies. We have discovered a new family member involved in mucosal immunity called IFN epsilon which has special functions in the female reproductive tract. Another aspect of signaling is negative regulation, particularly that mediated by the SOCS family of cytokines. We are investigating their regulation of IFN (α, β and γ) as well as TLR signaling. One outcome of the nature of our research is a growing capability in cell based screens for activators and inhibitors of innate immunity signaling. We are investigating the global nature of TLR/cytokine/interferon signaling using transcriptomics incorporated with bioinformatics to predict regulatory networks and identify novel transcriptional regulation candidates. One outcome is the INTERFEROME.org database for annotating response pathways. We have a longstanding expertise in the generation of genetically modified mice and their pathophysiological characterisation. Disease models include viral and bacterial infections and models of tumourigenesis. .

Techniques/Expertise

Molecular signaling (protein-protein interactions, IP-Westerns, kinases)
Screening assays for inflammation, infections
Generation and characterisation of genetically modified mice
Animal models of infectious disease, inflammation and cancer
Bioinformatics and Microarray profiling (human and mouse)
Gene regulatory mechanisms ( EMSA, translocation, ChIP, reporters, promoter mapping)
Flow cytometry
Immunoassays (antibody-based; cell mediated, immpunophenotyping, monoclonal generation)

Collaborations

Prof Jamie Rossjohn
Prof Elizabeth Hartland
B. Parker (Peter MacCallum) – Innate immune pathways in metastasis
L.O’Neill (Trinity College, Dublin) – TLR signaling
E. Latz (Bonn, Germany) – PRR signaling
Hong Tang (CAS, Beijing) – infection and immunity
Prof. Phil Hansbro, University of Newcastle, Australia
Prof. Doug Gollenbock -U.Mass. USA, Prof. Tervor Lawley, Sanger Inst., UK
Dr Nollaig Bourke TrinityCollege, Dublin

Disease Models

Variety of viral and bacterial infection models in mice
Induced and transplantable tumour models, e.g. mammary and ovarian.

Genetically Modified Organisms

Assorted genetically modified mouse models associated with TLR signaling, cytokine signaling (IFNs IFNARs, STATs, SOCS, etc) and ETS transcription factors (ETS1, ETS2, ELF3, ELF5, GABPa). Include conventional and conditionally targeted lines.

Other Lab Members

Dr Nicky de Weerd
Jodee Gould
Tony Matthews
Dr Jamie Gearing
Dr Helen Cumming
Zoe Marks
Dr Eveline de Geus
Stephanie Huang
Dr San Lim

Other members with similar research interests

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Dr Catherine Kennedy

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

A/Prof Ashley Mansell

Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research SEE FULL PROFILE >

Dr Ross Chapman

Centre for Immunity and Infectious Disease Hudson Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Feb 20

    Lorne Infection and Immunity Conference 2019

    Cumberland Lorne Resort MORE INFO
  • Sep 15

    14th World Congress of Inflammation

    MORE INFO
  • Feb 19

    Lorne Infection and Immunity Conference 2020

    150 Mountjoy Parade, Lorne VIC 3232 MORE INFO