Dr Michael Gantier

Group Leader
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research

michael.gantier@monash.edu

Contract research opportunities

Screening of molecules impacting the cGAS-STING pathway
pathway
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Latest News

Australian students looking for a PhD are welcome to contact us!

Research Activities

Our laboratory is interested in defining how nucleic acids control the interface between host and pathogens, and how this can lead to inflammatory diseases (as seen in Systemic Lupus Erythematosus).
With several new nucleic acids-based therapies now approved for use in humans (to treat diseases such as spinal muscular atrophy), understanding how synthetic nucleic acids can influence normal immune responses is important. In addition, synthetic nucleic acids can be devised to curb pathogens infections, presenting high potential against emerging global threats. Finally many chemotherapies directly interact with nucleic acids, indirectly engaging our immune system.  
Our group has made significant findings relevant to these themes – for instance recently describing how acriflavine, a century old antiseptic which binds DNA, can also induce immune responses protective against viruses.

Techniques/Expertise

Sensing of endogenous DNA products by the cGAS-STING pathway
miRNA research - dynamic modulation of innate immune responses
TLR7/8 biology - RNA sensing including sensing of viruses and intracellular bacteria

Collaborations

Prof Bryan Williams
Dr Cameron Stewart
Prof Eicke Latz
Dr Mark Behlke
Prof Wei Duan
Dr Claire McCoy
Dr Di Wu
Dr Michelle Tate
A/Prof Richard Ferrero
Prof Veit Hornung
Prof Paul Hertzog
Dr Seth Masters
Prof Eric Morand
Dr Jaclyn Pearson
Dr Sam Forster

Disease Models

Viral infections (IAV, rhinovirus, SFV), SLE, Salmonella and H pylori infections. 

Other Lab Members

Dr Genevieve Pepin

Other members with similar research interests

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Dr KE TANG

Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research SEE FULL PROFILE >

Prof Paul Hertzog

Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research SEE FULL PROFILE >

A/Prof Peter Revill

Molecular Research and Development Victorian Infectious Diseases Reference Laboratory SEE FULL PROFILE >

Upcoming Events

  • Feb 19

    Lorne Infection and Immunity Conference 2020

    150 Mountjoy Parade, Lorne VIC 3232 MORE INFO
  • Feb 20

    19th International Congress on Infectious Diseases

    Kuala Lumpur Convention Centre MORE INFO
  • Feb 27

    Antimicrobials 2020

    Melbourne Exhibition and Convention Centre MORE INFO