Dr Michael Gantier

Group Leader
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research

michael.gantier@monash.edu

Contract research opportunities

Screening of molecules impacting the cGAS-STING pathway
pathway
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Latest News

Australian students looking for a PhD are welcome to contact us!

Research Activities

Our laboratory is interested in defining how nucleic acids control the interface between host and pathogens, and how this can lead to inflammatory diseases (as seen in Systemic Lupus Erythematosus).
With several new nucleic acids-based therapies now approved for use in humans (to treat diseases such as spinal muscular atrophy), understanding how synthetic nucleic acids can influence normal immune responses is important. In addition, synthetic nucleic acids can be devised to curb pathogens infections, presenting high potential against emerging global threats. Finally many chemotherapies directly interact with nucleic acids, indirectly engaging our immune system.  
Our group has made significant findings relevant to these themes – for instance recently describing how acriflavine, a century old antiseptic which binds DNA, can also induce immune responses protective against viruses.

Techniques/Expertise

Sensing of endogenous DNA products by the cGAS-STING pathway
miRNA research - dynamic modulation of innate immune responses
TLR7/8 biology - RNA sensing including sensing of viruses and intracellular bacteria

Collaborations

Prof Bryan Williams
Dr Cameron Stewart
Prof Eicke Latz
Dr Mark Behlke
Prof Wei Duan
Dr Claire McCoy
Dr Di Wu
Dr Michelle Tate
A/Prof Richard Ferrero
Prof Veit Hornung
Prof Paul Hertzog
Dr Seth Masters
Prof Eric Morand
Dr Jaclyn Pearson
Dr Sam Forster

Disease Models

Viral infections (IAV, rhinovirus, SFV), SLE, Salmonella and H pylori infections. 

Other Lab Members

Dr Genevieve Pepin

Other members with similar research interests

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Dr Jim Harris

Centre for Inflammatory Diseases Monash Medical Centre SEE FULL PROFILE >

Dr Sammy Bedoui

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Seth Masters

Inflammation Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Jun 3

    7th International Symposium on Antimicrobial Peptides (AMP2020)

    Institut Pasteur MORE INFO
  • Jun 3

    Australasian Society for Infectious Diseases (ASID) Annual Scientific Meeting 2020

    Pullman Melbourne on the Park MORE INFO
  • Jun 3

    Impact of Environmental Changes on Infectious Diseases (IECID) 2020

    James Cook University, Singapore