Dr Ben Croker

Associate Professor
Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, School of Medicine, UCSD Center for Immunity, Infection, and Inflammation
University of California, San Diego

bcroker@ucsd.edu

Latest News

b-glucan dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment.

Neutrophils transfer pathogens to macrophages in a novel process called shuttling. The transfer of fungal pathogens is facilitated by Dectin-1 expression on macrophages. 

V Pazhakh*, F Ellett*, BA Croker*, Joanne A. O’Donnell, L Pase, KE Schulze, RS Greulich, A Gupta, CC Reyes-Aldasoro, A Andrianopoulos, GJ Lieschke. b-glucan dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment.  PLoS Biol 2019, 17(9): e3000113. *contributed equally. PMID: 3148377

Research Activities

The production, function, and death of neutrophils is critical for host defense against pathogens. The laboratory studies a novel phenomena called shuttling, which involves the transfer of intracellular pathogens from neutrophils to macrophages. We also investigate how cell death signaling controls cytokine secretion, NET formation, and neutrophil lifespan.

References
V Pazhakh*, F Ellett*, BA Croker*, Joanne A. O’Donnell, L Pase, KE Schulze, RS Greulich, A Gupta, CC Reyes-Aldasoro, A Andrianopoulos, GJ Lieschke. β-glucan dependent shuttling of conidia from neutrophils to macrophages occurs during fungal infection establishment.  PLoS Biol 2019, 17(9): e3000113. *contributed equally. PMID: 3148377

AA D’Cruz, M Speir, M Bliss-Moreau, S Dietrich, S Wang, AA Chen, M Gavillet, A Al-Obeidi, KE Lawlor, JE Vince, M Kelliher, R Hakem, M Pasparakis, DA Williams, M Ericsson, BA Croker. MLKL activates PAD4-dependent NET formation in necroptotic neutrophils. Science Signaling 2018, 11, eaao1716. PMID: 30181240

Techniques/Expertise

Neutrophils, HSC, Cell Death

Disease Models

MRSA, Bone Marrow Failure, Neutrophilic Dermatoses, Sudden Cardiac Death

Genetically Modified Organisms

Ripk1, Shp1, Kcnj8, Dectin-1, Mlkl

Research Images

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