Dr Ashraful Haque

Laboratory Head
Immunology
QIMR Berghofer Medical Research Ins

ashraful.haque@qimrberghofer.edu.au

Latest News

We have demonstrated that Type I IFN signalling impairs CD4+ T helper 1 responses in mice infected with blood-stage Plasmodium parasites.  This immunological suppression acts on conventional dendritic cells in the spleen, and serves to impair parasite control.  

Research Activities

We research the interactions that occur between the malaria-causing parasite, Plasmodium, and cells of the mammalian immune system. Symptoms of malaria in humans occur after the parasite infects red blood cells, with severe, and fatal disease often occurring in patients with the largest numbers of parasites in their bodies.Our aim is to understand how infected red blood cells can be detected and cleared from the body by the immune system, and importantly, why this process so often fails. We research novel strategies for improving parasite clearance, to inform the development of better vaccines and immune-therapies against malaria.

Techniques/Expertise

Our approach has been to generate new tools and techniques to study Plasmodium parasites in well-established experimental malaria models. We are currently focused on understanding how Plasmodium interactions with dendritic cells and macrophages controls both the outcome of infection, and the onset of adaptive immunity to malaria.

Disease Models

murine blood-stage malaria models

Other Lab Members

Kylie R James
Ismail Sebina
Megan Soon

Other members with similar research interests

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Dr Paul Ramsland

School of Science RMIT University SEE FULL PROFILE >

Dr Oanh Nguyen

Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

Dr Helen Cumming

Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Apr 25

    World Malaria Day

  • Apr 29

    International Day of Immunology

  • May 6

    37th European Society for Paediatric Infectious Diseases Annual Meeting

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