Dr Ashraful Haque
Department of Microbiology and Immunoloty
University of Melbourne, Doherty Institute
We recently employed single-cell transcriptomics and epigenomics to examine the onset of memory in CD4+ T cells during experimental malaria. This work can be viewed as a pre-print (not yet peer-reviewed) here: https://www.biorxiv.org/content/10.1101/675967v1), with a graphical user interface at https://malariaimmunology.shinyapps.io/cd4_dynamics/
Research ActivitiesWe have two main areas of interest:1) We are interested in how T cells respond during various clinically relevant scenarios, including but not limited to infection with malaria-causing Plasmodium parasites.
2) We are interested in how Plasmodium parasites sense and respond to the host during infection.
Techniques/ExpertiseWe have a focus on using single-cell genomics techniques and computational methods for studying immune cells as well as malaria parasites.
CollaborationsProf Miles P Davenport
Prof Sarah Teichmann
Dr. Roser Vento-Tormo
Prof Geoffrey R Hill
Dr. Antiopi Varelias
Dr. Motoko Koyama
Prof. Christian R Engwerda
Prof James S McCarthy
Prof Bill Heath
Dr. David S Khoury
Dr. Sumaira Hasnain
Prof Lachaln Coin
Disease ModelsMouse models of blood-stage malaria
Other Lab MembersDr. Hyun Jae Lee
Dr. Marcela Moreira
Dr. Michael Bramhall