Dr Ashraful Haque

Laboratory Head
Immunology
QIMR Berghofer Medical Research Ins

ashraful.haque@qimrberghofer.edu.au

Latest News

We have demonstrated that Type I IFN signalling impairs CD4+ T helper 1 responses in mice infected with blood-stage Plasmodium parasites.  This immunological suppression acts on conventional dendritic cells in the spleen, and serves to impair parasite control.  

Research Activities

We research the interactions that occur between the malaria-causing parasite, Plasmodium, and cells of the mammalian immune system. Symptoms of malaria in humans occur after the parasite infects red blood cells, with severe, and fatal disease often occurring in patients with the largest numbers of parasites in their bodies.Our aim is to understand how infected red blood cells can be detected and cleared from the body by the immune system, and importantly, why this process so often fails. We research novel strategies for improving parasite clearance, to inform the development of better vaccines and immune-therapies against malaria.

Techniques/Expertise

Our approach has been to generate new tools and techniques to study Plasmodium parasites in well-established experimental malaria models. We are currently focused on understanding how Plasmodium interactions with dendritic cells and macrophages controls both the outcome of infection, and the onset of adaptive immunity to malaria.

Disease Models

murine blood-stage malaria models

Other Lab Members

Kylie R James
Ismail Sebina
Megan Soon

Other members with similar research interests

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Dr Seth Redmond

Institute of Vector Borne Disease Monash University SEE FULL PROFILE >

Dr Alyssa Barry

Infection and Immunity Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Prof Bryan Williams

Hudson Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Jun 20

    ASM Microbe 2019

    Moscone Center 747 Howard St. San Francisco, CA 94103 MORE INFO
  • Jun 27

    4th Asia-Pacific AIDS & Co-Infections Conference

    MORE INFO
  • Jun 30

    Annual Meeting of the Australian Society for Microbiology 2019

    Adelaide Convention Centre MORE INFO