Dr Michael Gantier

ARC Future Fellow
Centre for Cancer Research
Hudson Institute of Medical Research

+61 3 8572 2709
michael.gantier@monash.edu

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Australian students looking for a PhD are welcome to contact us!

Research Activities

Our laboratory is interested in defining how nucleic acids control the interface between host and pathogens, and how this can lead to inflammatory diseases (as seen in Systemic Lupus Erythematosus).
With several new nucleic acids-based therapies now approved for use in humans (to treat diseases such as spinal muscular atrophy), understanding how synthetic nucleic acids can influence normal immune responses is important. In addition, synthetic nucleic acids can be devised to curb pathogens infections, presenting high potential against emerging global threats. Finally many chemotherapies directly interact with nucleic acids, indirectly engaging our immune system.  
Our group has made significant findings relevant to these themes – for instance recently describing how acriflavine, a century old antiseptic which binds DNA, can also induce immune responses protective against viruses.

Techniques/Expertise

Sensing of endogenous DNA products by the cGAS-STING pathway
miRNA research - dynamic modulation of innate immune responses
TLR7/8 biology - RNA sensing including sensing of viruses and intracellular bacteria

Collaborations

Prof Bryan Williams
Dr Cameron Stewart
Prof Eicke Latz
Dr Mark Behlke
Prof Wei Duan
Dr Claire McCoy
Dr Di Wu
Dr Michelle Tate
Dr Maria Liaskos
A/Prof Richard Ferrero
Prof Veit Hornung
A/Prof Marcel Nold
Prof Paul Hertzog

Disease Models

Viral infections (IAV, rhinovirus, SFV), SLE, Salmonella and H pylori infections. 

Other Lab Members

Dr Jonathan Ferrand
Dr Genevieve Pepin
Ms Charlotte Nejad

Other members with similar research interests

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Dr Matt Firth

Molecular Immunology Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Dr Le Son Tran

Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research SEE FULL PROFILE >

Dr Seth Masters

Inflammation Division Walter and Eliza Hall Institute of Medical Research SEE FULL PROFILE >

Upcoming Events

  • Feb 14

    Lorne Infection and Immunity Conference 2018

    Cumberland Lorne Resort REGISTER | MORE INFO
  • Mar 1

    18th International Congress on Infectious Diseases

    Sheraton Buenos Aires MORE INFO
  • Mar 15

    Eradicate Cancer 2018

    Melbourne Convention and Exhibition Centre MORE INFO