A/Prof Ashley Mansell

VIIN Executive Committee Member
Laboratory Head
Centre for Innate Immunity and Infectious Diseases
Hudson Institute of Medical Research

+61 3 9594 7215
ashley.mansell@monash.edu

Research Activities

Pattern Recognition Receptors based research investigating:
  • The Toll-like receptor (TLRs), RIG-like Helicase (RLHs) and NOD-like receptors (NLRs)
  • Signal transduction pathways initiated upon recognition of both pathogen and endogenous TLR ligands
  • Structure/Function analysis of TLR signaling mediators
  • Negative regulation of these pathways to prevent chronic inflammation
  • Pathogen immunomodulation of these pathways/receptors

Techniques/Expertise

activation of NF-kB and IFNγ by various means
cell biology
TLR screening
Viral infections
TLR expressing cell lines
TLR/PRR/Signaling pathway
immortalized gene-deficient BMMs
Inflammasome Imaging

Collaborations

Luke O'Neill, Trinity College Dublin
Katherine Fitzgerald, University of Massachusetts
Eicke Latz, University of Bonn
Bostjan Kobe, University of Queensland
Prof Phillip Nagley
A/Prof Richard Ferrero
Julie McAuley (Peter Doherty Institute)
Andrew Bowie, Trinity College Dublin
Nick Gay, Cambridge University
Douglas Golebock, Universitiy of Massachusetts
Prof Brendan Jenkins
Michelle Baker, CSIRO, AAHL
Dr Michelle Tate

Disease Models

Septic Shock
Viral Infection
Inflammasome
Influenza A virus
E. coli

Genetically Modified Organisms

Mal-/-, Mal D96N
Mul1 KO
ASC-/-
NLRP3-/-

Other Lab Members

Dr Jen Dowling, Post-Doctoral Fellow
Ms Anita Pinar, PhD Student
Mr James Ong, PhD Student

Other members with similar research interests

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Prof Colby Zaph

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

Dr Alison West

Centre for Innate Immunity and Infectious Diseases Hudson Institute of Medical Research SEE FULL PROFILE >

A/Prof Alex Andrianopoulos

Department of Genetics University of Melbourne SEE FULL PROFILE >

Upcoming Events

  • Sep 25

    Global Virus Network Meeting 2017

    Doherty Institute, Melbourne, Australia MORE INFO
  • Oct 16

    LISSSD 2017

    Sofitel Fiji Resort and Spa MORE INFO
  • Oct 16

    VIIN Young Investigator Symposium 2017

    Walter and Eliza Hall Institute MORE INFO