Research Activities

Our basic research focuses on the bioinformatic and computational analysis of large-scale human population cohort datasets that include a microbial component, typically metagenomic sequences from the gut or other body sites. We address a range of clinical, biological and ecological questions on host-microbe association, interaction and function as well as the influence of microbes (commensals or pathogens) and the gut microbiota on health and disease, including metabolic and cardiovascular diseases. Our scientific interests are generalist and fundamental at heart, but a few topics are of particular interest: – The ecology of bacterial pathogens in the healthy human gut and their association with non-communicable diseases.

• Genetic basis of pathogenic variation and association with human or animal disease.
• Effect of antibiotic and non-antibiotic medication on the gut microbiome and gut resistome dynamics.
• Exploring the links between the gut microbiota and host genetics, diet, disease incidence.

Research Keywords

Researching in the following areas: Infectious diseases, Antimicrobial resistance, Gut microbiome, Microbial genomics, Microbiology