Prof Jian Li

Senior Research Scientist
Monash Institute of Pharmaceutical Sciences
Monash University

+61 3 9903 9702
jian.li@monash.edu

Research Activities

Pharmacokinetics and pharmacodynamics of polymyxins against multidrug-resistant 'superbugs', in particular Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae (NHMRC and NIH funded projects)
Mechanisms of activity and resistance of polymyxins (NHMRC funded projects)
Discovery of novel lipopeptides and natural products against Gram-negative polymyxin-resistant 'superbugs' (NHMRC and DIISR funded projects)
Combination of antimicrobial agents (NHMRC and NIH funded projects)
Chemotherapy for infections in patients with cystic fibrosis
Novel anti-pathogenic agents
Integration of pharmacokinetic and pharmacodynamic principles to assist in antimicrobial development, to reduce resistance development and to optimize efficacy in the clinical use of antimicrobial agents
Lead optimisation of new antimicrobial entities

Techniques/Expertise

Susceptibility testing including: minimum inhibitory and bactericidal concentrations; fractional inhibition concentrations (for combinations); population analysis profiles
Time-kill experiments and post-antibiotic effect experiments (in vitro and in vivo)
In vitro Pharmacokinetic/Pharmacodynamic (PK/PD) infection model
In vitro biofilm model
Animal infection models (mouse thigh and mouse lung)
Quantitative analysis of drugs in biological fluids (using HPLC, LC/MS and bioassays) Pharmacokinetics of antimicrobials in small animals, including hepatic and renal handling of drugs and metabolites
Structure-activity relationships of polymyxin peptides against Gram-negative pathogens
Discovery and purification of novel antimicrobial agents from natural products

Collaborations

Professor John Turnidge (Women's and Children's Hospital)
Professor David Paterson (Royal Brisbane and Women's Hospital)
Professor Alan Forrest (State University of New York at Buffalo, USA)
Dr Brian Tsuji (State University of New York at Buffalo, USA)
Dr Juergen Bullita (Ordway Research Institute, USA)
Associate Professor Denis Spelman (Alfred Hospital)
Professor Jeff Lipman (University of Queensland)
Drs Ian Larson, Tony Velkov, Phil Thompson, Jamie Simpson, Ben Boyd, David Morton, Richard Prankerd, Michelle McIntosh and Prof Chris Porter (Monash Institute of Pharmaceutical Sciences, Monash University)
Dr Patrick Hartley (CSIRO, Clayton)
Dr Alexandre Prehn Zavascki (Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul, Brazil)
Professor Yue-zhong Li (Shandong University, China)
Prof Roger Nation
Dr John Boyce
Dr Marina Harper
Prof Ben Adler
Dr Ben Howden

Disease Models

Mouse thigh infection model
Mouse lung infection model

Other Lab Members

Postdoc fellows:
Drs John Hale
Gong Chen
Hee Ji Lee
Research Assistant:
Anima Poudyal
Heidi Yu
Caron Ku
Rebecca Nightingale
Jovan Jacob
Kathryn Davis
Shahan Khokhar
PhD students:
Phillip Bergen
Stephanie J. Wallace
Rajesh Dudhani
Robin Tan
Rachel L. Soon
Jumana Yousef
Shalini Yapa
Teresa Jong
Liang Jin
Jennifer Moffatt.

Other members with similar research interests

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Dr Catherine Kennedy

Department of Microbiology and Immunology University of Melbourne SEE FULL PROFILE >

A/Prof Phil Sutton

Infection and Immunity Theme Murdoch Childrens Research Institute SEE FULL PROFILE >

Prof Roger Nation

Monash Institute of Pharmaceutical Sciences Monash University SEE FULL PROFILE >

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