A/Prof Neil O'Brien-Simpson

Program Leader
Melbourne Dental School
University of Melbourne

+61 3 9341 1550
neil.obs@unimelb.edu.au

Research Activities

  1. Host repsonse to bacterial outer membrane vesicles (OMVs)
  2. Vaccine design and development - synthetic peptides and recombinant proteins
  3. Evaluation of the host response to bacterial oral infection
  4. Role of γδT cells, NKT cells and innate immune cells in bacterial oral infection
  5. Antimicrobial peptide development

Techniques/Expertise

  1. Peptide synthesis and modification, HPLC etc.
  2. Flow cytometry, Bioplex, MACS and FACS sorting, T cell proliferation, cytokine assays (ELISPOT, Bioplex), cell culture (T cells and subsets, B cells, macrophages, epithelial, endothelial etc)

Collaborations

2. Prof Dale Godfrey (Dept Immunology and Microbiology, University of Melbourne).
3. Prof Malcolm McConville (Dept Biochemistry, University of Melbourne)1
Prof John Wade (Howard Florey Institute)
Prof Greg Qiao (Dept Engineering, University of Melbourne)
Dr Maria Liaskos

Disease Models

Bacterial induced bone loss
bacterial induced periotonitis

Genetically Modified Organisms

αβ-TCR-/-, γδTCR-/-, IL-4-/-, IL-13-/-

Other Lab Members

Ms Yan Tan (Research assistant)
Ms Gail Brammar (Research assistant), two PhD students
Dr Jason Lenzo
Dr James Holden

Other members with similar research interests

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Dr Andrew Bean

Australian Animal Health Laboratory CSIRO SEE FULL PROFILE >

Dr Rebecca Gorrell

Department of Biochemistry and Molecular Biology Monash University SEE FULL PROFILE >

Dr Maria Liaskos (Kaparakis-Liaskos)

Department of Physiology, Anatomy and Microbiology La Trobe University SEE FULL PROFILE >

Upcoming Events

  • Oct 29

    Cytokines 2017

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  • Nov 1

    12th AUSTRALIAN INFLUENZA SYMPOSIUM 2017

    Peter Doherty Institute of Infection and Immunity REGISTER |
  • Nov 2

    Australian Respiratory Virology Meeting

    Peter Doherty Institute of Infection and Immunity REGISTER |